Our Research

Over the last 4 years, Cingulum Health has published 7 cohort studies examining patient outcomes and treatment variables in stroke, anxiety, major depression, traumatic brain injury, post-neurosurgical deficits, and sleep quality in affective disorders.

1. Anxiety Paper (n = 28)

  • Significant anxiety reduction using parcel-guided aTBS.

  • Common targets were left 8Av and PGs; minor side effects only.

2. Depression Paper (n = 26)

  • 62% reached remission post-treatment; 68% at follow-up.

  • Quality of life improved across all patients.

3. Post-Surgical (Craniotomy) Paper (n = 12)

  • All patients showed EQ-5D improvement.

  • One case showed 88% BDI reduction; no adverse events.

4. Sleep Quality Paper (n = 27)

  • Sleep, mood, and EQ-5D scores improved after treatment.

  • Sleep gains correlated with quality of life.

5. TBI/Post-Concussive Syndrome Paper (n = 19)

  • 100% improved on EQ-5D

  • 55% of depressed and 80% of anxious patients responded.

6. Tinnitus Paper (n = 9)

  • 75% improved on TRQ; 100% on THI.

  • No major side effects; most targets were non-auditory

Last year Cingulum published the largest safety study to date of connectome-guided whole brain TMS. This safety study shows that targeting beyond the standard dlPFC—into functionally abnormal regions identified by fMRI—is both feasible and safe, even in vulnerable populations like stroke and post-craniotomy patients.

Over the last 4 years, Cingulum Health has published 7 cohort studies examining patient outcomes and treatment variables in stroke, anxiety, major depression, traumatic brain injury, post-neurosurgical deficits, and sleep quality in affective disorders.

1. Anxiety Paper (n = 28)

Significant anxiety reduction using parcel-guided aTBS.

cgTMS Assisted Therapy

cgTMS is a non-invasive form of brain stimulation that uses a patient’s unique brain map (or connectome) to target gentle magnetic pulses to induce brain plasticity. By combining cgTMS with therapies, a synergistic effect is produced that is often more effective, leading to lasting improvements in mood, cognition, and motor function.

Specialist Care

You will meet with specialists who are trailblazers and experts in their respective fields. Our doctors believe in treating the person, not the diagnosis.

Cingulum Publications

  • Personalized, parcel-guided non-invasive transcranial magnetic stimulation for the treatment of post-concussive syndrome: safety and proof of concept

    Brain Injury, October 2024

    19 patients diagnosed with TBI and a heterogeneous mix of neuropsychiatric  symptoms saw significant improvement in quality of life after TMS treatment and at follow up.

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  • Improvements in sleep quality in patients with Major Depressive and Generalized Anxiety Disorders treated with individualized, parcel-guided TMS

    Brain and Behaviour, October 2024

    27 patients with affective disorders  experienced significant improvements in sleep, quality of life, depressive, and anxiety symptoms after TMS and at follow-up.

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  • An Agile, Data-Driven Approach for Target Selection in rTMS for Anxiety Symptoms

    Brain and Behaviour, May 2023

    28 patients with a diagnosis of generalised anxiety disorder saw a significant reduction in symptoms after TMS treatment at Cingulum Health.

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  • Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept

    Journal of Neuro-Oncology, November 2022

    12 patients with neurocognitive and functional deficits after tumour resection, saw significant improvement in quality of life post TMS treatment.

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  • Systems, Personalised, and Precision Medicine

    Dr. Mark Ryan, Consulting Psychiatrist

    May 2024

    Ethics, methodology and epistemology.

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  • Changes in the Brain Connectome Following Repetitive TMS for Stroke Rehabilitation

    Cureus, October 2021

    Case report of a patient treated at Cingulum with TMS, 19 months after an ischemic stroke, who saw significant improvement in speech and upper limb functional mobility.

    READ MORE

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